| Name | Graduation Year | Drafted by |
| Harry Ables | 1904 | Browns (Baltimore Orioles) |
| Frank Allen | 1909 | Brooklyn Dodgers |
| Curt Walker | 1919 | New York Yankees |
| Reds Ostergard | 1921 | Chicago White Sox |
| Carl Reynolds | 1927 | Chicago White Sox |
| Bill Losak | 1967 | Cleveland Indians |
| Steve Dubinka | 1974 | Pittsburgh Pirates |
| Ronnie Maynard | 1978 | Cincinnati Reds |
| Monty Harris | Kansas City Royals | |
| Steve Wendtland | 1978 | Montreal Expos |
| Kim Mason | 1980 | Montreal Expos |
| Scott Terry | 1982 | Cincinnati Reds |
| Bryan Neal | 1982 | Atlanta Braves |
| Tony Neuendorff | 1982 | Atlanta Braves |
| Phil Wellman | 1985 | Atlanta Braves |
| Dan Mickan | 1984 | Baltimore Orioles |
| Scott Neal | 1984 | Pittsburgh Pirates |
| Jeff Livin | 1984 | Houston Astros |
| Mike Cavers | 1987 | Baltimore Orioles |
| Mike Anderson | 1988 | Cincinnati Reds |
| Dan Cohen | 1991 | Atlanta Braves |
| Mike Timlin | 1988 | Toronto Blue Jays |
| Mike Stanton | 1989 | Atlanta Braves |
| Drue Reeves | 1992 | Cincinnati Reds |
| Roy Nieto | 1997 | Houston Astros |
| Matt Gelotti | 2000 | Milwaukee Brewers |
| Forrest Martin | 2003 | Milwaukee Brewers |
| Kurt Watzek | 2004 | Evansville Otters |
| Chris Caudill | 2006 | Cincinnati Reds |